Prooxidant-antioxidant profile in tissues of rats under the action of thiosulfonate esters

Thiosulfonates are characterized by a wide spectrum of biological activity and have effective antimicrobial, antithrombotic, antitumor antiparasitic effects. However, the use synthetic sulfur-containing compounds for therapeutic preventive purposes requires study their effect on protective mechanisms maintaining homeostasis, antioxidant status body in particular. The aim was to estimate lipid peroxidation process state system kidneys, spleen, brain, muscles rats under influence newly synthesized S-alkyl esters thiosulfonic acids S-ethyl-4-aminobenzenethiosulfonate (ETS), S-allyl-4-aminobenzenethiosulfonate (ATS) S-allyl-4-acetylaminobenzenethiosulfonate (AATS). Male Wistar kept standard diet were divided into four groups 5 animals each: I (control), II, III, IV (experimental). control group received additional 0.5 ml oil experimental solution thiosulfonate once day. III given ETS, ATS, AATS at rate 100 mg per kg weight. hydroperoxides (LPH), TBA-active products, GSH content SOD, catalase, glutathione peroxidase, reductase tissue homogenates determined. multidirectional changes studied indicators after consumption 21 days been identified indicating different degree inhibition or activation LPO processes depending type structure ester. Keywords: system, rat tissues, S-allyl-4-acetylaminobenzenethiosulfonate, S-allyl-4-aminobenzenethiosulfonate,